| Actor/Actress |
Role |
| Wesley Snipes |
Blade |
| Kris Kristofferson |
Whistler |
| Ron Perlman |
Reinhardt |
| Leonor Varela |
Nyssa |
| Norman Reedus |
Scud |
| Thomas Kretschmann |
Damaskinos |
| Luke Goss |
Nomak |
| Matt Schulze |
Chupa |
| Danny John-Jules |
Asad |
| Donnie Yen |
Snowman |
| Karel Roden |
Kounen |
| Marit Velle Kile |
Verlaine |
| Tony Curran |
Priest |
| Daz Crawford |
Lighthammer |
| Santiago Segura |
Rush |
| Samuel Le |
Jigsaw |
| Marek Vašut |
Golem |
| Pete Lee-Wilson |
Blood Bank Doctor / Reaper |
| Paul Kasey |
Blood Bank Guard / Reaper |
| Andrea Miltner |
Blood Bank Nurse |
| Ladislav Beran |
Drug Dealer |
| Jiří Maria Sieber |
Blood Bank Guard |
| Bridge Markland |
Vampire with Exposed Spine |
| Jamie Wilson |
Reaper |
| Stuart Luis |
Reaper |
| Ladislav Mohyla |
Reaper |
| Jan Malík |
Reaper |
| Jan Révai |
Reaper |
| Mário Wild |
Reaper |
| Tomás Böhm |
Reaper |
| Zdenek Bubák |
Reaper |
| Jan Loukota |
Reaper |
| Jan Bursa |
Reaper |
| Petr Krusalnicky |
Reaper |
| Jaroslav Misek |
Reaper |
| Karel Vávrovec |
St. Cloud |
| Jaroslav Peterka |
Choad |
| Milos Kulhavy |
Little G |
| Ivan Mares |
Tea Bag |
| Lennox Brown |
Man in London Porno Shop |
| André Hyde-Braithwaite |
Young Blade |
| Pavel Cajzl |
Moscow Vampire (uncredited) |
| Olga Lounová |
Prostitute (uncredited) |
| Stephen R. Peluso |
Paramedic (uncredited) |
| John Salvitti |
Moscow Vampire Attacking Blade (uncredited) |
| Rey-Phillip Santos |
Bandaged Reaper (uncredited) |
| Kenji Tanigaki |
Moscow Vampire Attacking Blade (uncredited) |
| Michael Woods |
Moscow Vampire Attacking Blade (uncredited) |
