| Actor/Actress |
Role |
| Ray Romano |
Manny (voice) |
| John Leguizamo |
Sid (voice) |
| Denis Leary |
Diego (voice) |
| Seann William Scott |
Crash (voice) |
| Josh Peck |
Eddie |
| Peter Dinklage |
Captain Gutt (voice) |
| Wanda Sykes |
Granny (voice) |
| Jennifer Lopez |
Shira (voice) |
| Queen Latifah |
Ellie (voice) |
| Josh Gad |
Louis (voice) |
| Keke Palmer |
Peaches |
| Nick Frost |
Flynn (voice) |
| Aziz Ansari |
Squint (voice) |
| Drake |
Ethan |
| Nicki Minaj |
Steffie (voice) |
| Alan Tudyk |
Milton / Hunky Siren (voice) |
| Ester Dean |
Female Siren (voice) |
| Kunal Nayyar |
Gupta |
| Rebel Wilson |
Raz (voice) |
| Eddie 'Piolin' Sotelo |
Uncle Fungus (voice) |
| Joy Behar |
Eunice (voice) |
| Alain Chabat |
Silas |
| Heather Morris |
Katie (voice) |
| Chris Wedge |
Scrat (voice) |
| Christopher Campbell |
Creature Siren (voice) |
| Jason Harris |
Additional Voices |
| Karen Disher |
Scratte |
| Lucas Leguizamo |
Additional Voices (voice) |
| Allegra Leguizamo |
Additional Voices (voice) |
| Jason Fricchione |
Dumb Mammoth / Various (voice) |
| Ben Gleib |
Marshall (voice) |
| George Jacobs |
Beaver (voice) |
| James Palumbo |
Panicked Start (voice) |
| Simon Pegg |
Buck (voice) |
| Alexandra Romano |
Meghan (voice) |
| Patrick Stewart |
Ariscratle (voice) |
| Brian Scott McFadden |
Additional Voices (voice) |
| Ashley Albert |
Additional Voices (voice) |
| Edita Brychta |
Additional Voices (voice) |
| Dennis T. Carnegie |
Additional Voices (voice) |
| Aimée Castle |
Additional Voices (voice) |
| Jim Conroy |
Additional Voices (voice) |
| Marieve Herington |
Additional Voices (voice) |
| Jason Harris |
Additional Voices (voice) |
| Sondra James |
Additional Voices (voice) |
| Alexa Kahn |
Additional Voices (voice) |
| Bill Lobley |
Additional Voices (voice) |
| Chris Phillips |
Additional Voices (voice) |
| Tara Sands |
Additional Voices (voice) |
| Keith Silverstein |
Additional Voices (voice) |
